Cart Call

Home > Disease > Paget's Disease - Causes, Symptoms, Treatment & Diagnosis | Max Lab

Paget's Disease - Causes, Symptoms, Treatment & Diagnosis | Max Lab

Paget's Disease - Causes, Symptoms, Treatment & Diagnosis | Max Lab

Paget's disease of bone (commonly known as Paget's disease or osteitis deformans) is a condition that occurs when the bone cells become dysregulated and start breaking down bone prematurely, often creating disorganized new bone growth. These changes weaken the bones, which can cause deformity, pain, breakage or arthritis in associated joints.

What is Paget's Disease?

Paget's disease is a disorder of bone, where the new bone tissue is unable to replace the old. The pelvis, skull, spine and legs are most likely to be affected and bones become more brittle and warped over time.

Over age 50, Paget's disease of bone could be a risk. But what's different these days is that the disease is less common and less severe when it does show up. Possible complications include broken bones, hearing loss, and pinched nerves in the spine.

Bisphosphonates are the main treatment option for bone weakness. In cases where complications arise, surgery may be necessary.

Causes of Paget's Disease

There are a variety of different potential causes of Paget's disease, and the exact cause may differ from person to person. Some potential causes include:

  • Inherited genetic mutations: Several genes have been identified as being associated with an increased risk of developing Paget's disease. These genes are often passed down from family members.
  • Bone trauma: Injury to the bones, such as a fracture or surgery, can trigger the development of Paget's disease.
  • Infection: Infections, such as those caused by bacteria or viruses, can sometimes lead to Paget's disease.
  • Inflammatory conditions: Inflammatory conditions, such as rheumatoid arthritis or Crohn's disease, can sometimes cause Paget's disease.

Signs and Symptoms of Paget's Disease

Paget's disease is a condition that causes the bones to become abnormally thickened and misshapen. Bone discomfort is Paget's disease's most prevalent symptom. Other symptoms include:

  • Joint pain
  • Muscle weakness
  • Fatigue
  • Frequent fractures
  • Deformities of the affected bones

If you think you may have Paget's disease, it is important to see your doctor for an evaluation. Early diagnosis and treatment can help prevent serious complications from developing.

Diagnosis of Paget's Disease

There are several methods for diagnosing Paget’s disease. The most common method is to take a bone biopsy. This involves taking a small sample of bone from the affected area and examining it under a microscope.

Other diagnostic tests include blood tests, X-rays, and MRI or CT scans. These tests can help to rule out other conditions that may cause similar symptoms.

A diagnosis of Paget’s disease is usually made based on the results of these tests, as well as the person’s symptoms and medical history.

Treatment for Paget's Disease

There is no cure for Paget’s disease, but treatments can help to relieve symptoms and prevent complications.

The main treatment for Paget’s disease is medication. The most common type of medication used is bisphosphonates. These drugs work by slowing down the rate of bone turnover, which can help to reduce pain and improve bone density.

Other medications that may be used to treat Paget’s disease include calcitonin and denosumab. In some circumstances, surgery may also be a possibility.

If you have Paget’s disease, it’s important to see your doctor regularly so that the condition can be monitored and treated if necessary.

Prevention for Paget's Disease

There is no known prevention for Paget’s disease. However, because the condition is thought to be caused by a combination of genetic and environmental factors, it may be possible to reduce your risk of developing the condition by making lifestyle choices that promote bone health. Some suggestions include:

  • Getting adequate calcium and vitamin D through diet or supplements
  • Exercising regularly
  • Not smoking
  • Avoiding excessive alcohol consumption

When to seek a doctor?

If you think you may have Paget’s disease, see your doctor. He or she will ask about your medical history and perform a physical examination. Your doctor may also order blood tests and imaging tests, such as X-rays, to help confirm the diagnosis.


Paget's disease is a serious condition that can cause a number of health problems. If you think you may have Paget's disease, it's important to see a doctor so that you can get the treatment you need. With proper treatment, most people with Paget's disease can live normal, healthy lives.

Want to Book a Blood Test

Other diseases

Get a Call Back from our Health Advisor


Get access to your orders, lab tests

OTP will be sent to this number by SMS

Not Registered Yet? Signup now.


OTP sent successfully to your mobile number

Didn't receive OTP? Resend Now

Welcome to Max Lab

Enter your details to proceed